The primary medications for treating hyperthyroidism are propylthiouracil and methimazole. Both drugs have similar side effects, and long-term use requires attention to the following aspects:1. Impact on white blood cells. Thyroid medications require regular blood tests as both drugs can cause a decrease in white blood cells and platelets, potentially leading to agranulocytosis in severe cases.2. Liver function damage. Both oral medications can cause liver damage, resulting in elevated liver enzymes. If liver enzymes exceed 2.5 times the normal level, the medication should be discontinued. If below 2.5 times, liver-protective treatment can continue.3. Allergic rashes. Approximately 5-10% of patients may develop allergic rashes after taking the medication, and some patients may experience autoimmune diseases such as ANCA-associated vasculitis.Therefore, patients with hyperthyroidism should regularly monitor liver function and blood tests to prevent adverse effects of the medication.