Cirrhosis can lead to endocrine disorders, primarily due to abnormal liver function, reduced inactivation of estrogen, and increased estrogen secretion. When liver function declines, the liver cannot promptly eliminate excess estrogen, aldosterone, and antidiuretic hormone, leading to their excessive accumulation in the body. The increase in estrogen, through a negative feedback mechanism, inhibits the pituitary gland's secretion, resulting in decreased androgen and adrenal corticosteroid production. These hormonal changes often manifest as endocrine imbalances and also suppress the production of male hormones. Female patients may experience irregular menstruation, amenorrhea, or infertility. Male patients may develop gynecomastia, a condition where the male breasts enlarge, which is not typical in normal males. Additionally, male patients may experience hair loss, reduced facial and body hair, and decreased libido.