For the treatment of melanoma, surgical resection should be performed for early-stage, non-metastatic lesions.

The extent of normal skin around the lesion to be excised should be determined based on its depth.

If it is a melanoma of the nail, amputation can be considered.

The involved lymph nodes should be removed, but prophylactic lymph node resection remains controversial.

Limb arterial perfusion and the use of anti-mitotic drugs for the treatment of limb melanoma have a certain therapeutic effect.

For patients with extensive metastases, combination chemotherapy and radiotherapy can be used.

Biochemical therapy and molecular targeted drug therapy hold great promise.