When diabetic nephropathy progresses to uremia, generally speaking, the survival rate is related to the complications of diabetes. Patients with diabetic nephropathy often develop hypoproteinemia and malnutrition due to massive proteinuria. Problems with heart function are often the leading causes of death in patients with chronic kidney disease. Currently, diabetic nephropathy has become the main cause of chronic renal failure. Approximately 30 - 40% of diabetic patients develop diabetic nephropathy each year. Once diabetic nephropathy progresses to overt nephropathy, it will continue to progress and ultimately lead to end - stage renal disease.