Sperm liquefaction refers to the phenomenon where semen becomes liquid within a certain period after ejaculation. Failure of sperm to liquefy can lead to infertility. Under normal circumstances, if liquefaction does not occur within 30 minutes after ejaculation, it should be taken seriously. This indicates potential issues with sperm motility, preventing them from reaching the female uterus and resulting in failed conception. There are various reasons for non-liquefaction, such as insufficient fibrinolysin, prostatitis, or other inflammations. It can also be related to emotional stress or dietary habits. When non-liquefaction occurs, it is essential to undergo relevant medical examinations and receive targeted treatment based on the results. Otherwise, it can have adverse effects on both physical and mental health.