There are two methods for staging gallbladder cancer. One is the Nevin staging, which is based on the depth and scope of lesion invasion and is mainly divided into five stages.
1. Stage I: carcinoma in situ within the mucosa
2. Stage II: invasion of the mucosa and muscular layer
3. Stage III: invasion of the entire layer of the gallbladder wall
4. Stage IV: invasion of the entire layer of the gallbladder wall with regional lymph node metastasis
5. Stage V: invasion of the liver and metastasis to other organs
The other is the TNM staging, which divides gallbladder cancer into four stages and is relatively more complex.
1. Stage I: invasion of the mucosa and muscular layer
2. Stage II: invasion of the entire layer of the gallbladder wall
3. Stage III: invasion of the liver less than 0.79 inches (2 centimeters) with regional lymph node metastasis
4. Stage IVA: invasion of the liver more than 0.79 inches (2 centimeters)
5. Stage IVB: distant lymph node or organ metastasis