The lesions of multiple sclerosis are categorized into demyelinating lesions in the brain and spinal cord. Lesions in the brain are typically less than 1 centimeter in diameter, usually ranging from 0.3 to 1 centimeter, and are scattered around the periventricular area, corpus callosum, brainstem, and cerebellum, with a few located at the gray-white matter junction.In the spinal cord, multiple sclerosis lesions are more commonly found in the cervical and thoracic regions, exhibiting various shapes such as small scattered dots, plaques, round or oval forms, and occasionally irregular patches. Some lesions may merge and are predominantly distributed in the white matter of the spinal cord's periphery. These lesions are generally larger than 3 millimeters in diameter but rarely extend beyond two vertebral segments, with minimal spinal cord swelling.