In a normal person's liver, the echo of the liver parenchyma is uniform. When the liver echo shows a rough change, ultrasound refers to it as a diffuse change of the liver, indicating that the liver has a certain degree of damage.However, this doesn't have any specific significance because it can also occur in normal people. For example, as people age, organs undergo degenerative changes. Factors such as diet, alcohol consumption, medications, and the environment can all lead to similar changes in the liver.But it's essential to rule out the liver parenchyma echo roughness caused by viral hepatitis or other pathological factors.Therefore, when the liver echo changes, patients are generally advised to first undergo a series of hepatitis tests and relevant liver function tests to rule out pathological conditions.