The side effects of Bisoprolol Fumarate include: 1. Mild fatigue, chest tightness, dizziness, bradycardia, drowsiness, palpitations, headache, and lower limb edema may occur during the initial stages of medication, but these symptoms generally diminish or disappear with continued use. 2. In rare cases, gastrointestinal disturbances (diarrhea, constipation, nausea, abdominal pain) and skin reactions (such as erythema and itching) may occur. 3. Occasionally, a significant drop in blood pressure, slow pulse, or atrioventricular conduction abnormalities may be observed. 4. Sometimes, a tingling sensation or cold extremities may occur, and in very rare cases, muscle weakness, painful muscle cramps, and reduced tear production may result. 5. For patients with intermittent claudication or Raynaud's phenomenon, symptoms may worsen initially, and those with pre-existing heart failure may experience an exacerbation of their condition. 6. Occasionally, airway resistance may increase. 7. In elderly patients with diabetes, glucose tolerance may decrease, and hypoglycemic symptoms (such as rapid heartbeat) may be masked.