Splenomegaly, especially in patients with liver disease, doesn't necessarily mean cirrhosis. Conversely, not all patients with cirrhosis have an enlarged spleen. During the progression of liver disease, due to the long - term influence of pathogenic factors, the liver suffers severe damage, leading to abnormal liver function metabolism and compensatory enlargement of the spleen. Additionally, the inflammatory lesions in the liver can cause the proliferation of reticuloendothelial cells in the spleen, resulting in splenomegaly. Another common cause is that the liver tissue fibrosis caused by chronic liver disease makes the blood vessels in the liver narrower, leading to portal hypertension. This blocks the blood return of the splenic vein, causing hypersplenism and subsequent enlargement of the spleen. This situation is commonly seen in patients with cirrhosis.